MateRegen® Gel: Intrauterine Adhesion Barrier after Hysteroscopy

Care of the uterine cavity is an important part of care after intrauterine procedures. MateRegen® Gel is a crosslinked hyaluronic acid gel that forms a temporary physical barrier between injured tissue surfaces during healing and is gradually absorbed. [1,2]

Support care of the uterine cavity

Injured endometrial surfaces may adhere after an intrauterine procedure. MateRegen is an intrauterine adhesion barrier designed to separate treated surfaces during healing, complementing appropriate surgical technique and clinical follow-up. [1]

Designed for intrauterine workflow

• Self-crosslinked hyaluronan: A gel network based on non-animal-sourced HA.
• Viscous consistency: Designed to remain at the target site and separate injured tissue surfaces.
• Temporary barrier: Product information describes degradation over approximately 7–14 days.
• 3 mL and 5 mL presentations: Confirm product codes and delivery accessories for the supplied configuration. [1]

Role after hysteroscopic surgery

MateRegen is intended as a barrier to prevent or reduce postoperative intrauterine adhesions following hysteroscopic surgery. Preparation, aseptic delivery, volume and accessories must follow the product-specific instructions and the clinician's treatment plan. [1]

Clinical evidence in context

Li and colleagues' multicenter randomized trial, published in 2019, enrolled 300 patients undergoing D&C for delayed miscarriage without previous D&C. Three-month data were available for 274 women. Intrauterine adhesions occurred in 9.5% of the gel group versus 24.1% of controls (p = 0.0012). [3]

This supports the role of crosslinked hyaluronan gel in the studied setting. It does not establish the same outcome for every procedure or guarantee complete adhesion prevention. Adhesion outcomes, clinical pregnancy and live birth are distinct endpoints; reduced adhesions do not guarantee a pregnancy or live birth.

MateRegen and HyaRegen: match the application

MateRegen focuses on the uterine cavity in 3 mL and 5 mL presentations. HyaRegen addresses adhesion barriers in gynecological surgery, particularly the abdominopelvic area, in a 10 mL presentation. Follow the indications and instructions for the actual product. [1]

Read more: HyaRegen for gynecological surgery.

Information for clinics and hospitals

• Product: MateRegen® Gel / Intrauterine Adhesion Barrier Gel.
• Manufacturer: BioRegen Biomedical (Changzhou) Co., Ltd.
• 3 mL: reference 40-008-011.
• 5 mL: reference 40-008-005.
• Confirm the presentation, delivery accessories, instructions, storage conditions and documentation applicable in Thailand. [1]

Connect product information with your team's needs

View MateRegen® Gel product information or contact Tawanmcweis for presentation details, supporting literature and an institutional quotation.

For healthcare professionals. Use must follow the indications, Instructions for Use and treating clinician's judgment.

References

1. BioRegen Biomedical. MateRegen V2.4 and HyaRegen V2.4. 2023-08-21. Pages 1–2.
2. BioRegen: HyaRegen Gel / MateRegen Gel.
3. Li X, et al. J Minim Invasive Gynecol. 2019;26:94–99. DOI: 10.1016/j.jmig.2018.03.032.