HyaRegen® Gel: Adhesion Barrier for Gynecological Surgery

Postoperative care can begin before wound closure. HyaRegen® Gel is a crosslinked hyaluronic acid adhesion barrier for gynecological surgery in the abdominopelvic area. It forms a temporary physical layer over treated tissue surfaces during healing and is gradually absorbed. [1,2]

Create space for tissue recovery

Injured tissue surfaces may adhere during healing. An adhesion barrier complements careful surgical technique and postoperative follow-up by physically separating treated surfaces during repair. HyaRegen provides an absorbable gel format for this purpose. [1,2]

Designed around surgical workflow

• Self-crosslinked HA: A gel network made with biologically fermented hyaluronic acid.
• Viscous, mouldable consistency: Supports coverage of the intended tissue surfaces.
• Gradual absorption: Product information describes degradation and absorption over approximately 7–14 days.
• 10 mL prefilled syringe: Prepared for use according to the product instructions. [1]

Gynecological applications

HyaRegen is an absorbable adhesion barrier gel for preventing or reducing postoperative adhesions. Product information covers laparoscopic, hysteroscopic and open gynecological procedures. Actual use must follow the indications and instructions for the supplied product. [1,2]

A closer look at clinical evidence

Liu and colleagues' 2015 multicenter randomized study enrolled 216 women undergoing gynecological laparoscopy. Among 196 per-protocol completers, moderate or severe adhesions at 10 ovarian/tubal sites occurred in 9.8% of the gel group versus 27.7% of controls receiving saline. [3]

These are adhesion outcomes in a specific study population. They do not guarantee complete adhesion prevention or a pregnancy outcome for an individual patient.

HyaRegen and MateRegen: choose by application site

HyaRegen addresses adhesion barriers in gynecological surgery, particularly the abdominopelvic area, in a 10 mL presentation. MateRegen focuses on the uterine cavity, with 3 mL and 5 mL presentations in its product information. Selection must follow the actual application, indications and product-specific instructions. [1]

Read more: MateRegen for care after intrauterine procedures.

Product information for surgical and procurement teams

• Product: HyaRegen® Gel / Absorbable Adhesion Barrier Gel.
• Manufacturer: BioRegen Biomedical (Changzhou) Co., Ltd.
• Presentation: 10 mL.
• Reference code: 40-012-010.
• Request the instructions, storage requirements and documentation applicable to the supplied product in Thailand. [1]

Start a focused conversation about adhesion prevention

View HyaRegen® Gel product information or contact Tawanmcweis for specifications, supporting literature and an institutional quotation.

For healthcare professionals. Use must follow the indications, Instructions for Use and treating clinician's judgment.

References

1. BioRegen Biomedical. HyaRegen V2.4 and MateRegen V2.4. 2023-08-21. Pages 1–2.
2. BioRegen: HyaRegen Gel / MateRegen Gel.
3. Liu C, et al. J Minim Invasive Gynecol. 2015;22:853–863. DOI: 10.1016/j.jmig.2015.04.011.